Abstract
The circadian clock is an endogenous timekeeping network that integrates environmental signals with internal cues to coordinate diverse physiological processes. The circadian function depends on the precise regulation of rhythmic gene expression at the core of the oscillators. In addition to the well-characterized transcriptional feedback regulation of several clock components, additional regulatory mechanisms, such as alternative splicing, regulation of protein stability, and chromatin modifications are beginning to emerge. In this review, we discuss recent findings in the regulation of the circadian clock function in Arabidopsis thaliana. The involvement of chromatin modifications in the regulation of the core circadian clock genes is also discussed.
Highlights
Plants, like animals, exhibit rhythmic biological activity, with a periodicity of 24 h
The first evening clock gene known to be repressed by clock associated 1To (CCA1) and late elongated hypocotyl (LHY) is TIMING OF CAB EXPRESSION 1 (TOC1, known as PRR1), a member of the pseudo-response regulator (PRR) family whose mutation shortens the period [8] by binding to a motif within the TOC1 promoter called the evening element (EE) [15]
PRR9, PRR7, and PRR5 physically interact with a transcriptional co-repressor, TOPLESS, and this interaction is required for the transcriptional repression of CCA1 and LHY [44]
Summary
Like animals, exhibit rhythmic biological activity, with a periodicity of 24 h. PRR7, PRR5, and TOC1 sequentially expressed and repress the expression of CCA1 and LHY, hypocotyl (LHY).are. PRR9, and TOC1 are sequentially expressed and repress the as well expression of CCA1 and as well as their own the evening,components all of the previously as their own transcription. The interaction expedition (CHE) helps TOC1 bind to the promoters of CCA1 and LHY. The phosphorylation of PRR5 and splicing regulates activity of CCA1: under high temperatures, the SNW/ski-interacting. CCA1 alternative splicing, leadingwith to an form, CCA1β, due to the CCA1β/CCA1α and CCA1β/LHY dimers show reduced DNA binding activity to downstream targets. (e) Regulation of clock central oscillator TOC1 by chromatin modifications: in the morning, accumulated-CCA1/LHY, associated with the histone modification complex containing LDL1/2 and HDA6, attaches to the promoter of TOC1, thereby reducing the H3Ac and H3K4Me levels of TOC1. Black arrows indicate the activation of transcription
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
