The place of immunological methods of treatment in the management of acute leukaemia.

Abstract

The development of the syngeneic animal system permitted tumour transplantation experiments to be conducted without interference from genetically determinaled antigens, and provided systems in which acquired ‘neo-antigens’ could be studied. Under carefully manipulated conditions several different immunological manouevres were shown to be capable of slowing the growth of tumours in experimental animals (see review, Alexander, 1974), and the two most promising methods that emerged which were applicable to man were non-specific stimulation of the immune system using agents such as B.C.G. (Halpern, et al 1959) and specific stimulation with tumour cells (Haddow and Alexander, 1964).KeywordsAcute Myelogenous LeukaemiaAcute Lymphoblastic LeukaemiaAcute LeukaemiaHuman Leukaemia CellMaintenance ChemotherapyThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.