Abstract
FOR some time we have been assaying the various components of thyroglobulin and some derivatives of thyroxine. Recently we reported on the optical isomers of thyroxine (1) and on the bromine and chlorine analogues (2). The present report is a continuation of this type of study, which has a twofold purpose: 1. To learn of the role played by the several structural components of thyroxine in determining its physiologic activity. 2. To search for a compound which might depress the pituitary and the thyroid without increasing the oxygen consumption too greatly. Of the compounds assayed and reported subsequently in this article, the side chain is altered in two (n-acetyl l-thyroxine and n-acetyl dl-thyroxyl l-glutamic acid), the hydroxy group is substituted in one (methyl ether of thyroxine), the oxygen coupling of the two benzene rings is substituted by sulphur in one (sulphur analogue of thyroxine), and in one the position of the iodine atoms is altered (2′6′-diiodothyronine).
Published Version
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