Abstract
Less than one percent of marine natural products characterized since 1963 have been obtained from the phylum Bryozoa which, therefore, still represents a huge reservoir for the discovery of bioactive metabolites with its ~6000 described species. The current review is designed to highlight how bryozoans use sophisticated chemical defenses against their numerous predators and competitors, and which can be harbored for medicinal uses. This review collates all currently available chemoecological data about bryozoans and lists potential applications/benefits for human health. The core of the current review relates to the potential of bryozoan metabolites in human diseases with particular attention to viral, brain, and parasitic diseases. It additionally weighs the pros and cons of total syntheses of some bryozoan metabolites versus the synthesis of non-natural analogues, and explores the hopes put into the development of biotechnological approaches to provide sustainable amounts of bryozoan metabolites without harming the natural environment.
Highlights
Natural products have long been employed to ameliorate the quality of human life as nutrition and as fragrances, pigments, insecticides, and medical drugs [1]
One question arises in when discussing bioactive natural product, of especially one that by is bryostatins was similar between the two colony types, suggesting that the presence of the bryostatinproduced by a microbial associate, is how the host has adapted to the presence of these compounds, producingwhen symbionts affects expression in the host.InAnalysis the neritina especially the natural product target is a eukaryotic protein
We ran the NCI-developed COMPARE analysis [151] on tambjamine I (3i) and this analysis turned out to be negative with a cut-off value as low as 60% of correlation for 3i versus all the compounds already included in the Standard Agent database, which includes more than a thousand pro-apoptotic compounds
Summary
Natural products have long been employed to ameliorate the quality of human life as nutrition and as fragrances, pigments, insecticides, and medical drugs [1]. This review aims to provide how a holistic, multidisciplinary recently by several [10,11,12], this review summarizes selected compounds from account of the current state of affairs on this topic. It outlining outlines aspects about generalofbiology and bryozoans may complement existing treatments while the shortcomings current cancer evolutionary history of bryozoans and illustrates how bryozoans with the help of their metabolites treatments, as well as the problems and mechanisms associated with metastatic growth (Sections 3 shape chemoecologial interactions in the wild (Section 2).
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