Abstract
The light sensitive part of the rod photoreceptor, the outer segment, is continually renewed within the retinas of adult vertebrates. This process of membrane renewal consists of two distinct components, disk addition and disk shedding, which are maintained in a constant dynamic balance throughout adult life. Thus, although each rod outer segment loses approximately 10% of its length each day due to shedding and phagocytosis of rod tips by the adjacent pigment epithelial layer, the total length of the outer segment remains constant due to assembly of new disks at the base of the outer segment. The mechanisms of disk shedding and disk addition are, as yet, undefined although it appears that each phase of the overall disk renewal cycle may involve some cytoskeletal components.
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Schedule a callMore From: Proceedings, annual meeting, Electron Microscopy Society of America
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