Abstract
Lichen planus (LP) is a chronic, relapsing, non-infectious inflammatory disease affecting the skin and mucous membranes. The exact origin of oral lichen planus (OLP) is not well known. Complete spontaneous healing is rare. The treatment of oral lichen planus is palliative, and there is no curative treatment so far, which is a therapeutic challenge for practitioners. The goals of treatment are the control of pain, signs, and symptoms. Local corticosteroids remain the first-line treatment. In case of failure of drug therapy, other treatments can be considered, such as photodynamic therapy. Material and methods: Our work was carried out using the PubMed, ScienceDirect, and EBSCO search engines to explore the literature on the efficacy of photodynamic therapy in the treatment of lichen planus. Conclusion: Photodynamic therapy appears to have some effect in the treatment of OLP in adult patients. However, further randomized controlled trials with a long follow-up period, standardized PDT parameters, and comparison of PDT efficacy with steroid therapy are warranted to obtain firm conclusions in this regard.
Highlights
oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disease of unknown etiology and polymorphic appearance [1]
Researchers have found that contact of dental restorative materials with oral tissue may be associated with the development of lichenoid reactions that clinically and histologically resemble to OLP but have an identifiable etiology
The minimum inclusion requirements were studies on patients diagnosed with OLP and treated with photodynamic therapy (PDT) after topical administration of a PS, randomized controlled trials
Summary
OLP is a chronic inflammatory mucocutaneous disease of unknown etiology and polymorphic appearance [1]. Researchers have found that contact of dental restorative materials with oral tissue may be associated with the development of lichenoid reactions that clinically and histologically resemble to OLP but have an identifiable etiology. Trauma is an exacerbating factor by which other etiological factors may exert their effect; this partly explains why OLP lesions develop in sites prone to trauma, the oral mucosa or the lateral surfaces of the tongue [2,3,4,5,6,7,8,9,10,11] Psychosomatic disorders and their association with the LP remains controversial. Its radical reactions are very fast (< 0, 04 us) and of short action (< 0, 02 um) provoke the destruction and the death of the abnormal cells, without causing damages to the cells and the healthy tissue
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