Abstract
Following a single dose of dimethylnitrosamine (DMNA) the phosphorylation of rat liver ribosomes was strongly enhanced. The incorporation of [ 32P]phosphate into the 40 S subunit was stimulated 5- and 9-fold 2 and 5 hr, respectively, after administration of the drug. The phosphorylation of the large ribosomal subunit was not affected. The enhanced phosphorylation of the small subunit was due to a 20-fold stimulated incorporation of phosphate into ribosomal protein S6, the only one affected by DMNA.
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