Abstract
Background: Melanoma is a highly invasive and metastatic malignant tumor, with pathogenesis involving multiple signaling pathways and transcription factors. Current treatments face significant challenges, including drug resistance, toxic side effects, and recurrence. Purpose: This review aims to evaluate the therapeutic potential of natural products in the treatment of melanoma and to identify the associated challenges and future research opportunities. Methods: A comprehensive literature search was conducted using PubMed and Web of Science to identify studies reporting on natural products with antimelanoma activity. Results: Natural products demonstrate diverse pharmacological activities, including antiproliferative, proapoptotic, and antimetastatic effects, highlighting their potential in melanoma treatment. However, challenges such as limited efficacy, safety concerns, and the lack of standardized formulations remain significant barriers. Conclusion: This review provides insights into the therapeutic applications of natural products for melanoma, discusses existing limitations, and proposes future directions, contributing to the development of effective and safe antimelanoma treatments.
Published Version
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