Abstract
The PDPK1 gene, located on chromosome 16p13.3, encodes 3-phosphoinositide-dependent protein kinase (PDPK1). PDPK1 signaling in oocytes preserves reproductive lifespan by maintaining the survival of ovarian primordial follicles. One animal study showed that in mice lacking the PDPK1 gene in oocytes, the majority of primordial follicles are depleted around the onset of sexual maturity, causing premature ovarian failure (POF) during early adulthood. The study further showed that PDPK1 regulate the primordial follicles through PDPK1-Akt-p70 S6 kinase 1 (S6K1)-ribosomal protein S6 (rpS6) signaling in oocytes, indicating the importance of this pathway in controlling the survival.
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