Abstract
Introduction: The direct effect of parenteral nutrition on secretion of regulatory peptides in infants has not been yet reported. Aim: The aim of the study was the analysis of secretion of chosen regulatory peptides from the gut and adipose tissue in parenterally fed infants comparing to children fed orally as well as hydrated intravenously. Materials and Methods: In this study, the response of glucose, ghrelin, leptin, PYY, GLP1 and adiponectin to the enteral and parenteral feeding in babies has been investigated. We compared three groups of infants: formula-fed infants, infants on TPN and fasted, awaiting for general anaesthesia before CT examination, receiving an i.v. 5% Original Research Article Annual Research R and calorie intake and PYY concentration (r=0.76, p<0.001) as well CCK (r=0.50; p<0,005). Conclusions: The lack of fasting/postprandial modulation of secretion of gut peptides might be responsible for disturbed development of parenterally fed children. Adiponectin and PYY are the putative marker of short-term energy balance.
Highlights
The direct effect of parenteral nutrition on secretion of regulatory peptides in infants has not been yet reported
The ghrelin plasma concentrations during the total parenteral nutrition mimics the postprandial levels observed in enterally fed children
Energy consumption in group I was calculated from the volume of ingested formula-milk over 24 hours, taking into account the body weight and energy value of the consumed milk reported by the manufacturer
Summary
The direct effect of parenteral nutrition on secretion of regulatory peptides in infants has not been yet reported. Aim: The aim of the study was the analysis of secretion of chosen regulatory peptides from the gut and adipose tissue in parenterally fed infants comparing to children fed orally as well as hydrated intravenously. Materials and Methods: In this study, the response of glucose, ghrelin, leptin, PYY, GLP1 and adiponectin to the enteral and parenteral feeding in babies has been investigated. The ghrelin plasma concentrations during the total parenteral nutrition mimics the postprandial levels observed in enterally fed children. Due to the absence of typical oral feeding stimulants like proteins and fat, as well as the different point of delivery of the nutrients, serious disturbances in plasma concentrations of gastrointestinal peptides (like CCK, GLP-1, PYY, and ghrelin) and peptides from adipose tissue (like leptin and adiponectin) can be expected
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call