Abstract
In the present research the changes in the enzyme link of the antioxidative system as well as in the content of reduced erythrocyte glutathione and the oral liquid in patients suffering from type II diabetes mellitus, bronchial asthma, chronic obstructive lungs disorder and comorbidities of the researched diseases have been disclosed. The regularities in changes of the biochemical indices on the systemic and the local level have been revealed. As a rule in patients suffering from the pathology comorbidities the more apparent metabolic disorders have been indicated. The most essential changes in the erythrocyte suspension have been revealed in patients suffering from all the pathologies found three. The activity of superoxide dismutase has increased by 29 %, of catalase by 65 %, of glutathione reductase by 2,4 times while the activity of glutathione peroxidase has decreased by 3,3 times. The glutathione concentration in the same patient group has been 19 % down from the control indices. In the oral liquid of the same group the activity of superoxide dismutase as well as the one of glutathione reductase has increased by 81 % and 83 % respectively. The activity of glutathione peroxidase has not changed, the activity of catalase has decreased by 9,2 times. In general, the indices of patients suffering from the comorbidities have been closer to the pathologies of the respiratory system which proves the conception of the leading role of oxidative disorders in such patients.
Highlights
In the present research the changes in the enzyme link of the antioxidative system as well as in the content of reduced erythrocyte glutathione and the oral liquid in patients suffering from type II diabetes mellitus, bronchial asthma, chronic obstructive lungs disorder and comorbidities of the researched diseases have been disclosed
The most essential changes in the erythrocyte suspension have been revealed in patients suffering from all the pathologies found three
In the oral liquid of the same group the activity of superoxide dismutase as well as the one of glutathione reductase has increased by 81 % and 83 % respectively
Summary
In the present research the changes in the enzyme link of the antioxidative system as well as in the content of reduced erythrocyte glutathione and the oral liquid in patients suffering from type II diabetes mellitus, bronchial asthma, chronic obstructive lungs disorder and comorbidities of the researched diseases have been disclosed. В работе показаны изменения ферментного звена антиоксидантной системы и содержания восстановленного глутатиона эритроцитов и ротовой жидкости у больных сахарным диабетом 2-го типа, бронхиальной астмой, хронической обструктивной болезнью легких и сочетанными формами исследуемых заболеваний. Целью настоящей работы явилось изучение активности ферментов антиоксидатной защиты (каталаза, супероксиддисмутаза, глутатионредуктаза и глутатионпероксидаза) и содержания восстановленного глутатиона в крови и ротовой жидкости у больных с сочетанным течением СД 2-го типа с бронхиальной астмой и хронической обструктивной болезнью легких.
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