Abstract
In a simple, one-pot procedure, H2O2 has been utilised for the synthesis of unsymmetrical ureas from thioureas obtained by the reaction of aryl isothiocyanates with aliphatic secondary amines. The reaction proceeds via the formation of a thioamido guanidino moiety (the anti-Hugerschoff product) which then undergoes further oxidative desulfurization in the presence of excess H2O2 to afford the desired product. The scope of this phosgene free urea synthesis has been extended to various substrates.
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