Abstract

Reaction of 2-acetylamino-3, 3-dichloroacrylic-N-acetylamide (1) with aliphatic primary amines gave 2-acetylamino-2-(substituted amino)-3, 3-dichloropropionamides (3) as major products, which differs distinctly from the results of reaction of 1 with aliphatic secondary amines which leads to oxazole derivatives 2. The 3 compounds were also prepared by addition of aliphatic primary and secondary amines to 2-acetylamino-3, 3-dichloroacrylamide (6). Small amounts of 2-methyl-5-(substituted amino) oxazole-4-carboxamides (5) were obtained also. The mechanisms of these reactions are discussed.

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