Abstract
Background: Pressure-controlled inverse ratio ventilation (PC-IRV) was used in patients with acute respiratory distress syndrome (ARDS) after failed volume-cycled conventional ratio ventilation (VC-CRV). The aim of this study was to evaluate the outcome of early PC-IRV in severe ARDS. Methods: Twenty patients with severe ARDS were switched from VC-CRV to PC-IRV if they failed to maintain SaO 2 >90% by the following criteria: peak inspiratory pressure (PIP) >35 cm H 2O, FIO 2 = 60%, and positive end-expiratory pressure (PEEP) 10 cm H 2O. Results: The values of PIP, mean airway pressure, minute volumes, and lung injury score in VC-CRV were 43.9 ± 8.0 cm H 2O, 19.5 ± 6.4 cm H 2O, 11.0 ± 2.1 L/min, and 2.8 ± 0.2 respectively. In PC-IRV, the corresponding data were 31.8 ± 5.1 cm H 2O, 25.4 ± 4.6 cm H 2O, 8.3 ± 0.9 L/min, and 2.5 ± 0.4. All of these parameters were significantly different. Fifteen patients (75%) survived their intensive care unit stay. Conclusions: Early PC-IRV in severe ARDS improves oxygenation, facilitates tapering of high fraction of inspiratory oxygen, and decreases high PEEP or PIP, and then results in the improvement of the patient’s outcome.
Published Version
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