Abstract
Triamcinolone acetonide prepared (5 mg/ml and 0.5 mg/ml) in propylene glycol and (1 mg/g) in Orabase to which [ 3H]-triamcinolone acetonide was added was placed on the oral mucosa in plastic wells and biopsies taken at various periods after application, together with biopsies taken after a delay of 2 or 3 h following removal of applied samples. Biopsies were processed for serial sectioning and extraction or for autoradiography. There was a trend for the tissue concentration of triamcinolone acetonide to increase with time which was significant for the 5 mg/ml samples. Both serial sectioning and autoradiographic techniques showed the absorbed steroid to lie mainly within the epithelium and connective tissue immediately below the basement membrane. The total steroid in biopsies was significantly greater in the 5 mg/ml samples than in the 0.5 mg/ml or oral ointment samples. Progressive loss of steroid from the tissues following removal of the applied samples was apparent from biopsies taken 2 and 3 h after removal of applied samples.
Published Version
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