The Oral Microbiome Bank of China

Peng Xian,Li Yan,Li Yuqing,Su Xiaoquan,Liao Ga,Huang Shi,Xu Xin,Xu Jian,Li Jiyao,Zhou Xuedong

doi:10.1038/s41368-018-0018-x

Abstract

The human microbiome project (HMP) promoted further understanding of human oral microbes. However, research on the human oral microbiota has not made as much progress as research on the gut microbiota. Currently, the causal relationship between the oral microbiota and oral diseases remains unclear, and little is known about the link between the oral microbiota and human systemic diseases. To further understand the contribution of the oral microbiota in oral diseases and systemic diseases, a Human Oral Microbiome Database (HOMD) was established in the US. The HOMD includes 619 taxa in 13 phyla, and most of the microorganisms are from American populations. Due to individual differences in the microbiome, the HOMD does not reflect the Chinese oral microbial status. Herein, we established a new oral microbiome database—the Oral Microbiome Bank of China (OMBC, http://www.sklod.org/ombc). Currently, the OMBC includes information on 289 bacterial strains and 720 clinical samples from the Chinese population, along with lab and clinical information. The OMBC is the first curated description of a Chinese-associated microbiome; it provides tools for use in investigating the role of the oral microbiome in health and diseases, and will give the community abundant data and strain information for future oral microbial studies.

Highlights

In the process of individual development and growth, the oral microbiome changes dynamically; as age increases and dentition changes, physiological changes occur in the oral microbiome and the composition of microorganisms in different age groups has large specificity.[2,12,17]
Keijser et al found that oral microorganisms covered 318 genera of 22 phyla, 5600 and 10,000 of which were colonised in saliva and plaque, respectively.[15,18,19]
The new concept of the ‘oral core microbiome’ suggests that this phenomenon should be personalised in accordance with the ecological characteristics of the oral environment in certain populations at different ages or grades of disease.[15,16,39,73]

Summary

INTRODUCTION

With the development of microbiome research in recent years, studies have found that the human microbiome is closely related to systemic diseases.[1,2,3,4] At the end of 2007, the National Institutes of Health (NIH) launched the Human Microbiome Project, which aimed to resolve microorganisms by mapping the genomes of five major parts of the human body (buccal, nasal, vaginal, gut and skin microbiomes).[5,6] The oral microbial community and oral and systemic health are closely related; they can induce dental caries, apical periodontal disease, periodontal disease, pericoronitis, oral mucosal disease and other oral diseases and many systemic diseases.[7,8,9,10,11,12]. Our database the development of RA.[30,50] In addition, the oral microbiome may supports views, queries and Basic Local Alignment Search Tool serve as a ‘fingerprint’ for the development and treatment of RA.[51] A recent study found that there is significant ecological (BLAST), and free downloads of the information on bacterial strains are available. The group and serve oral microbiology researchers in China, the first results are listed by four main variables, including unique taxa ID, goal of this study was to develop a provisional taxonomic scheme separate no., bacteria name and disease association status. 16S_Sequence/Molecule_Confidence: The sequence of 16S rRNA and the identity of the 16S rRNA sequence

DISCUSSION

Findings

MATERIALS AND METHODS