Abstract
The homeobox gene Hox-2.4 is transcriptionally activated in cells of the mouse myeloid leukemia WEHI-3B. The constitutive Hox-2.4 expression in WEHI-3B cells is due to insertion of a transposable element belonging to the family of intracisternal A particles. In this study, we demonstrated the oncogenic potential of this activated homeobox gene. NIH 3T3 fibroblast clones bearing the activated Hox-2.4 gene produced fibrosarcomas in nude mice.
Highlights
We demonstrated the oncogenic potential of this activated homeobox gene
In our initial search for genomic changes of homeobox genes in tumor cells, we found a rearrangement of the Hox-2.4 gene in WEHI-3B mouse myeloid leukemia cells as a result of insertion of an intracisternal A particle (IAP) upstream of Hox-2.4 [4, 5]
All clones containing the IAP-Hox-2.4 gene expressed a high level of Hox-2.4 RNA, comparable to that in the WEHI-3B leukemic cells
Summary
The Oncogenic Potential of an Activated Hox-2.4 Homeobox Gene in Mouse Fibroblasts The homeobox gene Hox-2.4 is transcriptionally activated in cells of the mouse myeloid leukemia WEHI-3B. NIH 3T3 fibroblast clones bearing the activated Hox-2.4 gene produced fibrosarcomas in nude mice.
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