Abstract
The Obligate Intracellular Lifestyle
Highlights
In contrast to Rickettsia spp., intracellular development of C. burnetii and Chlamydia spp. occurs within a membrane-bound parasitophorous vacuole
This theme is further explored by Ouellette and Carabeo (2010)who describe an example of how obligate intracellular bacteria intimately interact with and depend on host resources
Similar to the case with their facultative cousins, secretion of host-interactive effector proteins represents a significant mechanism employed by obligate intracellular bacteria to promote virulence through modulation of host cell processes
Summary
In contrast to Rickettsia spp., intracellular development of C. burnetii and Chlamydia spp. occurs within a membrane-bound parasitophorous vacuole. Hussain et al (2011) investigated contributions of eukaryotic factors in formation of the C. burnetii-containing vacuole and present evidence that multiple host kinases are essential for vacuole biogenesis. This theme is further explored by Ouellette and Carabeo (2010)who describe an example of how obligate intracellular bacteria intimately interact with and depend on host resources.
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