Abstract
White mice and guinea pigs were exposed to the nuclear-polyhedrosis virus of Heliothis zea (Boddie) and Heliothis virescens (Fabricius). The virus was administered in the form of polyhedral inclusion bodies, free virus rods, or polyhedral protein by inhalation, per os feeding, or intravenous, intradermal, intraperitoneal, and intracerebral injections. One death occurred, caused by an acute pneumonia, in 155 virus-treated and 75 nonvirus-treated animals. The animals showed normal weight gains and no abnormalities or pathological conditions were detected.
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