Abstract
Cardiovascular, respiratory, and nervous systems neonatal pathology in premature babies leads to systemic and organ hypoxia, which is one of the main risk factors for premature retinopathy (PR) development. Among the certain neuron-specific proteins, the most studied and adequately characterizing the blood-brain barrier (BBB) proper membrane function is neuro-specific enolase (NSE), which is currently used to diagnose acute conditions characterized by cerebral ischemia and brain hypoxia, occurring with impaired BBB function.
Highlights
Improvements in neonatal care have led to a progressive decrease in preterm infants mortality rate with extremely low and very low birth weight [5,6]
A premature baby is at a reactive oxygen species-induced diseases increased risk such as premature retinopathy (PR), which leads to visual disability
Blood flow violation in the premature baby eye membranes leads to tissue ischemia, its edema and hypoxia, with the retina being affected [2,8].One of the risk factors for PR development in newborns is circulatory retinal hypoxia, which develops as the cardiovascular, respiratory, and nervous systems neonatal pathology result in premature infants and leads to systemic and organ hypoxia [2]
Summary
Improvements in neonatal care have led to a progressive decrease in preterm infants mortality rate with extremely low and very low birth weight [5,6]. A comparative study of blood serum parameters based on NSE content revealed significant differences between the newborns groups depending on the gestational age and the central nervous system damage degree. NSE increased level was noted on the 4th day of life in all groups children 94% cases when compared with the norm and averaged 63.6±8.3 mμg/ml was in group A premature infants, in premature babies in group B was 86.5±7.2ng/ml.
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