The Novel KI, WU and MC Polyomaviruses and Human Diseases

Abstract

From 2007 to 2012, the Polyomaviridae family expanded with the discovery of several novel human polyomaviruses. Infection by polyomaviruses is widespread in the human population, but only immunocompromised patients are at risk for disease. Currently, four polyomaviruses have been specifically associated with human diseases: BK polyomavirus, JC polyomavirus, Merkel cell polyomavirus and trichodysplasia spinulosa-associated polyomavirus. The pathogenic potential of the other human polyomaviruses is unknown. This review focuses on the novel Karolinska Institute polyomavirus, Washington University polyomavirus and Merkel cell polyomavirus. Karolinska Institute polyomavirus and Washington University polyomavirus were uncovered in respiratory specimens of children with acute respiratory symptoms. Merkel cell polyomavirus was found in an aggressive skin tumor named Merkel cell carcinoma. The scientific literature concerning the three human polyomaviruses is summarized and discussed including seroepidemiology, detection methods (real-time PCR), histopathological findings and association with clinical manifestations.