The novel H2S-releasing compound D-P* reduces inflammation in osteoarthritic chondrocytes and fibroblast-like synoviocytes

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Purpose: Hydrogen sulfide (H2S) is an endogenously produced gasotransmitter that seems to be involved in the regulation of a variety of processes, including inflammation, apoptosis, proliferation, ATP synthesis, or cellular respiration. The inorganic H2S-donor sodium hydrogensulfide (NaHS) has been shown to modulate inflammatory processes and cell differentiation in vitro and to have effects on mitochondrial dysfunction. Since NaHS is very unstable, we are looking for organic compounds that can serve as H2S donors and might have the potential to be used for the treatment of degenerative and inflammatory joint diseases, such as osteoarthritis (OA) and rheumatoid arthritis (RA).