The NO Level after Coronary Artery Bypass Graft under the Conditions of Artificial Circulation

Abstract

Objective:to study the nature of changes in the content of stable metabolites of nitric oxide (NOx) - nitrites and nitrates - in the blood of patients after coronary artery bypass graft (CABG) under the conditions of artificial circulation.Material and methods.Depending on the level of [Hb] in the blood plasma, the patients with CABG surgery were divided into three groups: 1 - without IOH (Hb ≤ 0.1 g/l), n = 43, 2 - with low IOH (l IOH, Hb > 0.1 g/l and < 0.5 g/l, n = 42), 3 - with high IOH (hIOH, Hb ≥ 0.5 g/l, n = 38). The level of NOx was determined in the blood plasma of the patients.Results.At the end of CABG, compared with the baseline, the patients revealed a decrease of NOx in the blood plasma and its increase - within 5-7 days after the surgery, to the utmost in the group with high IOH.Conclusion.The change of NOx in the blood plasma depended on the severity of intraoperative hemolysis, which indicates the influence of the hemolysis products on the formation and utilization of nitric oxide.