Abstract
• Our data showed that casp-1-dependent pyroptosis might be a key event in AKI in rat kidney transplant. • The NLRP3-Casp1-IL1β signaling pathway mediated AKI in rat kidney transplantation. • The NLRP3 inflammasome activation involved in renal allograft rejection was first reported. • Our data suggested that mcc950 may provide a novel approach in the renal allograft rejection.
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