The nigrostriatal projection in the cat: Part 1. Silver impregnation study

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The course and destination of the degenerating nigrostriatal fibers were studied by selective silver impregnation methods in 37 cats with unilateral lesions in the substantia nigra. The nigrostriatal fibers ascend along the dorsomedial border of the substantia nigra to the prerubral area; they proceed for a short distance through the lateral hypothalamus, enter the medial part of the internal capsule and run in a dorsorostral direction to reach the head of the caudate nucleus and the rostral portion of the putamen. A smaller number of degenerating fibers obliquely cross the peduncular part of the internal capsule and traverse the entopeduncular nucleus and the pallidum to terminate in the central and caudal portions of the putamen. Some features of the topical distribution of the nigrostriatal tract are described. Apparently, the more anterior part of the pars compacta sends axons primarily to the head of the caudate nucleus and to the most rostral putamen. The most medially situated nigral neurons project to the fundus striati. The posteromedial cell groups of the pars compacta innervate primarily the central putamen and the caudal part of the caudate nucleus. The projection of the lateral cell group of the posterior zona compacta to the caudal putamen is sparser than from the other nigral groups, suggesting that a part of them has another destination, possibly lower in the neuraxis. The contribution of the pars reticulata to the nigrostriatal connections seems to be modest, according to the small number of neurons; they project to the lateral caudate and putamen. Thus, the ascending nigrostriatal fibers mirror the distribution of the descending striatonigral fibers. No convincing evidence for the existence of a nigroentopeduncular and nigropallidal projection was found.