The newly detected pulmonary sarcoidosis in HIV-infected patients

Abstract

Objective — to determine the clinical, X-ray examination features in the newly detected sarcoidosis in HIV-infected patients.Materials and methods. Data of 6 HIV-infected patients (3 women, 3 men, middle age 42.4, range (28—61 years) with the newly detected sarcoidosis, that had been observed during 2006—2018 years. The level of CD4+-cells, signs or symptoms of disease, dependence of development of sarcoidosis on the terms of setting of АRT-treatment were considered. X-rays examinations (n = 6) and computer tomography (КТ) (n = 6) were performed, where next criteria: presence of lymphadenopathy, pulmonary nodules, interlobular septal thickening, focal consolidations, reticular opacities, ground glass opacity, cysts or fibrosis were considered.Results and discussion. The average interval between two diagnoses was 1 year. A level of CD4-cells s was 412 cells/µL (range of CD4+ 34—795 cells/µL). All patients had pulmonary signs or symptoms of sarcoidosis. X-rays examinations showed a lymphadenopathy, pulmonary nodules, focal consolidations, reticular opacities, ground glass opacity, and cysts. CТ scans showed a lymphadenopathy, pulmonary nodules, interlobular septal thickening, focal consolidations, reticular opacities, ground glass opacity.Conclusions. The X-ray examinations and clinical features in the newly detected pulmonary sarcoidosis in HIV-infected patients are analogical to sarcoidosis in nonHIV­infection patients. A level of CD4+-cells in most patients had more 200 cells/µL. Development of sarcoidosis depends from conservation or updating of level of CD4+ of lymph cells, and in the greater amount of cases, the level of CD4+ of lymph cells had been exceeded 200 cells/µL.