Abstract
The neuroprotective potential of ethanolic extract of Lagenaria vulgaris EELV seeds against Oxidative Stress in Rat Hippocampus was evaluated to ascertain the validity of folkloric claims The neuroprotective potential was evaluated through oxidative stress induced by sodium azide in the hippocampus of rats Brain homogenates were pre incubated for minutes with mg mL EELV and then incubated for minutes with mM sodium azide and were examined for oxidative markers viz thiobarbituric acid reactive substances TBARS catalase CAT superoxide dismutase SOD since their levels are altered on exposure to sodium azide The results indicated that the levels of TBARS CAT activity were enhanced and SOD activity was reduced by sodium azide EELV prohibited the changes in TBARS CAT and SOD Cell viability was evaluated by the dimethylthiazol yl diphenyl tetrazolium bromide MTT and it rsquo s showed no change in MTT reduction by Sodium azide However EELV increased MTT reduction in the presence or absence of sodium azide Hence it can be concluded that EELV has potential antioxidant and neuroprotective activity in the rat hippocampal homogenate which may be due to the presence of flavonoids
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