Abstract
The objective of work was to prepare and characterize solid dispersions of valsartan using beta Cyclodextrin to improve its aqueous solubility and rate of dissolution by solvent evaporation technique Solid dispersions showed marked improvement in the solubility behaviour and improved drug release From all the formulations VSD was found to be optimized formulation based on the characterization solubility and dissolution studies The results obtained showed that the aqueous solubility and rate of dissolution was significantly improved when formulated in solid dispersion as compare to pure drug The enhancement of dissolution rate depends on the nature and amount of the carrier and increases with the increase in the concentration of the carrier Increase in the dissolution rate may be attributed to the reduced particle size of drug deposited on the surface of carrier and enhanced wet ability of the drug particles by the carrier The optimized formulations were evaluated by differential scanning Calorimetry DSC Fourier transform infrared spectroscopy FTIR and Scanning electron microscopy SEM
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