Abstract
Although thiopental improved neurological outcomes in several animal studies, there are still insufficient clinical data examining the efficacy of thiopental for patients undergoing surgical clipping of unruptured intracranial aneurysm (UIA). This study validated the effect of thiopental and investigated risk factors associated with postoperative neurological complications in patients undergoing surgical clipping of UIA. In total, 491 patients who underwent aneurysm clipping were included in this retrospective cohort study. Data regarding demographics, aneurysm characteristics, and use of thiopental were collected from electronic medical records. Propensity score matching and logistic regression analysis were used. After propensity score matching, the thiopental group showed a lower incidence of the postoperative neurological complications than non-thiopental group (5.5% vs. 17.1%, p = 0.001). In multivariate analysis, thiopental reduced the risk of postoperative neurological complications (odds ratio (OR) 0.26, 95% confidence interval (CI) 0.13 to 0.51, p < 0.001) while aneurysm size ≥ 10 mm (OR 4.48, 95% CI 1.69 to 11.87, p = 0.003), and hyperlipidemia (OR 2.24, 95% CI 1.16 to 4.32, p = 0.02) increased the risk of postoperative neurological complications. This study showed that thiopental was associated with the lower risk of neurological complications after clipping of UIA.
Highlights
Unruptured intracranial aneurysm (UIA) has a reported incidence of up to 3% in the general population [1]
491 patients who had undergone surgical clipping of UIA were enrolled in this study
This study showed that aneurysm size and hyperlipidemia were independently associated with postoperative neurological complications in patients who underwent UIA clipping
Summary
Unruptured intracranial aneurysm (UIA) has a reported incidence of up to 3% in the general population [1]. Surgical clipping is considered suitable for the treatment of UIA. During surgical clipping of UIA, temporary clipping of parent artery is commonly performed to soften the UIA, thereby reducing intraoperative rupture and facilitating approach to vessels [2,3]. Temporary clipping is associated with cerebral ischemia and postoperative neurological complications [4,5,6]. Cerebral infarction occurs in approximately 11% of patients who have undergone surgical clipping of UIA [7]. Some measures, such as hypothermia, neurophysiologic monitoring, or pharmacological interventions, have been suggested to prevent neurological impairment after UIA clipping [8,9,10]
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have