Abstract
The neuronal membrane as a key factor in neurodegeneration
Highlights
The neuronal membrane is the site where most processes involved in neuronal preservation and functioning are triggered
These actions require the participation of membrane-related molecular agents, which associate in protein/lipid clusters to initiate molecular processing and signal transduction
Cholesterol impairment in the neuronal membrane has been related, among others, to Alzheimer’s disease (AD), prion diseases and autistic spectrum disorders, as it has been nicely illustrated by Anchisi et al (2013)
Summary
The neuronal membrane is the site where most processes involved in neuronal preservation and functioning are triggered. These actions require the participation of membrane-related molecular agents, which associate in protein/lipid clusters to initiate molecular processing and signal transduction. This Special issue composed by five outstanding Reviews and a very interesting Hypothesis and Theory work tackles different strategies and events taking place at the neuronal membrane related to neurodegeneration and neuroprotection against the most common form of dementia in the elderly, Alzheimer’s disease (AD) and Parkinson’s disease (PD).
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