Abstract
Kahn and coworkers examined cortical thickness in patients with schizophrenia over time. Measures of functional outcome, and cumulative intake of antipsychotic medication were also assessed. Two MRI scans were obtained over a 5-year interval of 96 schizophrenia patients and 113 healthy subjects between 16 and 56 years. Excessive cortical thinning was found in widespread areas on the cortical mantle, most pronounced bilaterally in the temporal and in the left frontal cortex. Poorer outcome was associated with more pronounced cortical thinning. Thus, the cortex shows excessive thinning over time, most pronounced in the frontal and temporal areas and progresses across the entire course of the illness.
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