The negative impact of local recurrence on overall survival in adult patients with extremity localized osteosarcoma

Abstract

Osteosarcoma is the most common primary malignant bone tumour in adults and is usually located in long bones. Standard treatment consists of perioperative chemo-therapy and radical surgical resection. In the case of the extremity location, the gold standard is limb-sparing surgery using various reconstructive techniques. Our study analyzed 175 adult patients in MSTS I-III stage treated for extremity os-teosarcoma at our institution between 2000 and 2017. The median observation was 41 months (3-225 months). 111 patients were treated with limb-sparing surgery, 80 patients had tumour resection followed by endoprosthetic reconstruction, 31 patients had local resection without reconstruction and 64 patients underwent amputation. 5-year OS (overall survival) and DFS (disease-free survival) rates in the study group were 62% and 52%, respectively, and life expectancy was 136 months. Local recurrence occurred in 34 (19%) patients in the whole group, including 16 (17%) patients after reconstruction, 11 (35%) patients after local resection and 7 (10%) patients who had an amputation. In the group of patients with local recurrence, 5-year OS rate was 30%, statistically significantly worse than patients without recurrence (5-year OS 70%).