Abstract

Antigen stimulated release of histamine from chopped sensitized guinea-pig lung is inhibited by the addition of β-adrenoceptor agonists in a manner indicating a β 2 response. Preaddition of β-adrenoceptor antagonists blocks this inhibition in a manner indicating a β 1 response. This apparent dichotomy probably results from a hybrid receptor, though the danger of the use of chemical analogues for classifying receptors is highlighted. Inhibition of histamine release by β-stimulation is shown to be species rather than organ specific.

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