Abstract
The β-adrenoceptor stimulants, isoprenaline (IPR), orciprenaline (OPR), terbutaline (TRB), and ITP ∗∗ were studied for effects on antigen-induced release of histamine from guinea-pig lung tissue and for effects on guinea-pig isolated trachea and heart. The order of potency for the agents in the four functions studied were: (a) inhibition of histamine release, IPR > OPR ≈ TRB ⪢ ITP = 0; (b) heart stimulation, chronotropic effect, IPR > OPR > ITP ≈ TRB; (c) heart stimulation, inotropic effect, IPR > OPR > ITP > TRB; (d) trachea relaxation: IPR > TRB > OPR ⪢ ITP. These findings suggest that the β-adrenoceptors mediating inhibition of antigen-induced release of histamine are more related to those mediating trachea relaxation ( β 2) than those mediating cardiac stimulation ( β 1).
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