The Nature of Post-Anaphylactic State in Guinea Pigs

Abstract

Summary Normal guinea pigs react to subcutaneous injection of diphenylformamidine hydrochloride by the same characteristic symptoms as those which appear in desensitized guinea pigs on the injection of chrysoidin in the post-anaphylactic state. The symptoms of the anaphylactic shock in guinea pigs in which a hydrochloric acid solution of antifebrine (acetanilide) was injected shortly before the reinjection, are expressed, as a rule, in very unusual forms. They become in this case identical with the symptoms which appear in animals in the period of post-anaphylactic state after subcutaneous injection of chrysoidin. Subcutaneous injection of some anti-shock preparations, in particular diphenylformamidine hydrochloride and di-phenylmethylpyrazolonyl, quickly and considerably increases in antimals (rabbits) the sugar content of blood.