The nature of kidney damage causing the development of acute renal failure in patients with COVID-19 (according to morphological studies)

Abstract

The literature review presents data on the study of the nature of kidney damage in patients with COVID-19 with acute renal insufficiency according to histo-morphological lifetime and postmortem studies of the kidneys during the peak of the epidemic of infection in 2020-2022. In the analysis, the role of direct viral damage to tissues and organ cells is questioned. The frequency of diagnosis of glomerular, tubular, interstitial and vascular lesions is specified, the significance of the presence of variants of the apolipoprotein-1 (APOL1) gene in patients with severe respiratory complications of acute viral infection is assessed.