Abstract
Cadmium has given conflicting results in tests for mutagenic activity. Gene mutation studies in bacteria and yeasts have been inconclusive, while rec‐assay has elicited a weak mutagenic response. Chromosomal aberrations were not observed in bone marrow cells of rodents treated with cadmium salts. Neither dominant lethal mutations nor heritable translocations have been seen. Observations on chromosomal aberrations following occupational exposure to cadmium have been conflicting. However in these studies mixed exposures had occurred. There is some evidence that cadmium interferes with spindle formation in mice and hamsters. Some of the positive results have been observed at borderline cytotoxic concentrations of cadmium suggesting that the mutagenic effect observed may have been an indirect one. A number of cadmium compounds have given rise to sarcoma following subcutaneous or intramuscular injection in rodents. In sufficient dosage, destruction of testicular tissue has been followed by interstitial cell hy...
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