Mutation, Cancer, and Malformation

Abstract

Genetic Factors in Human Diseases.- Environmental mutagenesis and disease in human populations.- Clinical genetics of human cancer.- Chromosome abnormalities in cancer development.- Mutations of cellular oncogenes as a basis for neoplastic change.- Human gene mapping in the analysis of oncogenes.- Basic Concepts in Mutagenesis and Carcinogenesis.- Relationship between mutagenesis and carcinogenesis.- Theoretical basis of mutagenesis.- DNA repair processes.- The Role of DNA repair in mutation induction.- Use of the Bacilussubtilus Rec-assay in environmental mutagen studies.- Mutagenesis in yeasts.- A comparison of genotoxic activity in somatic tissue and in the germ cells of Drosophilamelanogaster.- The P-factor: a transposable element in Drosophila.- Silkworm genetics and chemical mutagenesis.- Mutation induction and detection in Arabidopsis.- Mutagenesis studies with cultured mammalian cells: problems and prospects.- The control of cell transformation, mutagenesis and differentiation by chemicals that initiate or promote tumor formation.- Dominant-lethal mutations and heritable translocations in mice.- Recessive and dominant mutations in mice.- Benzo (a)pyrene and 6-nitrobenzo (a) pyrene metabolism in human and rodent microsomes and tissue culture.- Nitrosamine metabolism and carcinogenesis.- Modification of carcinogenesis by dietary and nutritional factors.- Naturally occurring mutagens.- Reproductive Toxicology.- Teratogenesis.- A possible mechanistic link between teratogenesis and carcinogenesis: inhibited intercellular communication.- Gem cell toxicity: significance in genetic and fertility effects of radiation and chemicals.- Environmental Toxicology, Mutagenesis, and Carcinogenesis.- The science of toxicology - scope, goals and four case studies.- Mutagenicity of pesticides.- Genetic toxicology of 14 agents casually associated with cancer in humans.- Sensitivity, specificity and accuracy of the Arabidopsis assay in the identification of carcinogens.- Environmental studies in Sweden.- Research progress on environmental mutagenesis, carcinogenesis and teratogenesis in China.- A. Strategy of approach to cancer control in China.- Toxicological research in public health: the Chinese experience.- Environmental mutagenesis research at Fudan University.- The role of risk assessment in regulatory decisions in the United States.- Alternate methods for integrated evaluation of toxicity and risk assessment.- Posters.