Abstract
A generation ago it was generally held that paralytic poliomyelitis was caused by a single virus. Studies subsequently have revealed three serotypes of poliovirus which are incorporated in Salk vaccine. By means of tissue culture and suckling mouse methods, two large families of viruses have been added and are now grouped with the polioviruses as a tribe of enteroviruses, the Coxsackie (A and B) and the ECHO virus families.<sup>1</sup> In selected instances the virus was isolated before the clinical significance was appreciated. This phenomenon led to the expression that these were "viruses in search of disease." Later they became associated with more or less well defined clinical syndromes, such as epidemic pleurodynia, herpangina, aseptic meningitis ("nonparalytic poliomyelitis"), pericarditis, myocarditis, encephalitis, and nondescript outbreaks of febrile misery. They bid fair to become great imitators of clinical entities. They may produce parotitis, with or without orchitis simulating mumps, and eruptive fevers
Published Version
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