Abstract
T-cell intracellular antigen 1 (TIA1) is an RNA-binding protein that is expressed in many tissues and in the vast majority of species, although it was first discovered as a component of human cytotoxic T lymphocytes. TIA1 has a dual localization in the nucleus and cytoplasm, where it plays an important role as a regulator of gene-expression flux. As a multifunctional master modulator, TIA1 controls biological processes relevant to the physiological functioning of the organism and the development and/or progression of several human pathologies. This review summarizes our current knowledge of the molecular aspects and cellular processes involving TIA1, with relevance for human pathophysiology.
Highlights
T-cell intracellular antigen 1 (TIA1) is an RNA-binding protein that is expressed in many tissues and in the vast majority of species, it was first discovered as a component of human cytotoxic T lymphocytes
TIA1 has a dual localization in the nucleus and cytoplasm, where it plays an important role as a regulator of gene-expression flux
This review summarizes our current knowledge of the molecular aspects and cellular processes involving TIA1, with relevance for human pathophysiology
Summary
Phylogenetic trees, cellular- and and tissular-expression tissular-expression profiling, profiling, and and Jensen. It does possess rich domain appear to be responsible accumulation in the nucleus, mediated a specific motif for nuclear localization,for theits. 3′-at the cytoplasm appears to be mediated by the RRM3 domain and its binding to RNAs. It should noted that when transcription is inhibited, adenosine uridine-rich sites be sequences) located in for the what3 -UTR ever reason, TIA1 accumulates cellthat cytoplasm [25] (Figure 2). It should in bethe noted when transcription is inhibited, for whatever reason, TIA1 accumulates in the cell cytoplasm [25] (Figure 2)
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