Abstract
The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes
Highlights
Mou, Fan, Maria Praskova, Fan Xia, Denille Van Buren, Hanno Hock, Joseph Avruch, and Dawang Zhou. 2012
Deletion of Mst1 and Mst2 from the lymphoid compartment reduces peripheral T cell number by 98% In contrast to the reduced numbers of naive T cells seen with deletion of Mst1, a global deletion of murine Mst2 caused no changes in lymphocyte numbers in any compartment, nor did Mst2 deletion alter the abundance of Nore1b/RAPL/Rassf5b or the phosphorylation of Mob1 in the thymus (Fig. 1 A)
The morphology of the secondary lymphoid organ (SLO) reflects the severe depletion of peripheral T cells; there was a complete loss of white pulp in the spleens of the Mst1/Mst2vavDKO mice, and their LNs were atrophic
Summary
Fan, Maria Praskova, Fan Xia, Denille Van Buren, Hanno Hock, Joseph Avruch, and Dawang Zhou. 2012. The Mst and Mst kinases control activation of rho family GTPases and thymic egress of mature thymocytes. Compared with wild-type mice, these double knockout (DKO) mice exhibit a severe reduction in the number of mature T cells in the circulation and in secondary lymphoid organs (SLOs). CD4+CD8 and CD4 CD8+ single-positive (SP) thymocytes in DKO mice resemble mature T cells of wild-type mice but undergo excessive apoptosis, and their egress from the thymus is reduced by >90%. T cell trafficking is critical to immune surveillance and to the generation of an effective immune response (Bromley et al, 2008) This trafficking is mediated by a set of chemotactic receptors, adhesion molecules, the cellular actin network, and its regulators
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