Abstract
The slender shape of axons makes them uniquely susceptible to mechanical stress. In this issue, Pan, Hu et al. (https://doi.org/10.1083/jcb.202206046) use a microfluidic axon-on-chip device to reveal how actomyosin protects axons from mild mechanical stress, by transiently adopting a beaded shape that helps limit the spread of damaging calcium waves.
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