Abstract
The Mouse Genome Database (MGD, http://www.informatics.jax.org) serves the international biomedical research community as the central resource for integrated genomic, genetic and biological data on the laboratory mouse. To facilitate use of mouse as a model in translational studies, MGD maintains a core of high-quality curated data and integrates experimentally and computationally generated data sets. MGD maintains a unified catalog of genes and genome features, including functional RNAs, QTL and phenotypic loci. MGD curates and provides functional and phenotype annotations for mouse genes using the Gene Ontology and Mammalian Phenotype Ontology. MGD integrates phenotype data and associates mouse genotypes to human diseases, providing critical mouse–human relationships and access to repositories holding mouse models. MGD is the authoritative source of nomenclature for genes, genome features, alleles and strains following guidelines of the International Committee on Standardized Genetic Nomenclature for Mice. A new addition to MGD, the Human–Mouse: Disease Connection, allows users to explore gene–phenotype–disease relationships between human and mouse. MGD has also updated search paradigms for phenotypic allele attributes, incorporated incidental mutation data, added a module for display and exploration of genes and microRNA interactions and adopted the JBrowse genome browser. MGD resources are freely available to the scientific community.
Highlights
The Mouse Genome Database (MGD, http://www. informatics.jax.org) [1,2,3] serves the international research community as the central resource for integrated genomic, genetic and biological data on the laboratory mouse
Since its inception 25 years ago, MGD has served as the authoritative source for mouse genes, genome features, mutations and strain nomenclature
It has become the source for the unified catalog of mouse genome features, the comprehensive set of Gene Ontology (GO) annotations for mouse protein-coding genes, the comprehensive source for mouse phenotype annotation using the Mammalian Phenotype (MP) Ontology and the connection between mouse genotypes and the human diseases that they model
Summary
The Mouse Genome Database (MGD, http://www. informatics.jax.org) [1,2,3] serves the international research community as the central resource for integrated genomic, genetic and biological data on the laboratory mouse. Informatics.jax.org) [1,2,3] serves the international research community as the central resource for integrated genomic, genetic and biological data on the laboratory mouse. These include: the development of the Human–Mouse: Disease Connection interface, which enables the exploration of relationships between human and mouse genes and phenotypes, and their connections to known human diseases; the addition of explicit gene–gene and gene–allele relationships that allow users access to interaction data, and that reveal genomic mutations encompassing multiple genes; the addition of incidental mutations data sets discovered through genome sequencing of N-ethyl-N-nitrosourea (ENU) mutagenized mice and their progeny; key improvements in phenotype querying that speed search performance and provide more precise searching for alleles; and implementation of the JBrowse [13] genome browser.
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