The Molecular Biology of Down Syndrome

Abstract

Molecular abnormalities of the brain in Down Syndrome: relevance to Alzheimer's neurodegeneration.- Reduced aldehyde dehydrogenase levels in the brain of patients with Down Syndrome.- The Down Syndrome critical region.- Neuropathology.- c-fos expression in brains of patients with Down Syndrome.- Neuronal cell death in Down's syndrome.- Altered expression in fetal Down Syndrome brain as revealed by the huntinG technique of subtractive hybridization.- expression in fetal Down Syndrome brain as revealed by subtractive hybridization.- Molecular misreadinG of Genes in Down syndrome as a model for the Alzheimer type of neurodegeneration.- Expression of the dihydropyrimidinase related protein 2 (DRP-2) in Down Syndrome and Alzheimer's disease brain is downregulated at the mRNA and dysregulated at the protein level.- expression relevant to Down Syndrome: problems and approaches.- Isolation and analysis of chromosome 21 Genes potentially involved in Down Syndrome.- Differential display reveals deteriorated mRNA levels of NADH3 (complex I) in cerebellum of patients with Down Syndrome.- Serotonin (5-HT) in brains of adult patients with Down Syndrome.- Mechanisms of neuronal death in Down's syndrome.- Impaired brain Glucose metabolism in patients with Down Syndrome.- Oxidative stress and neural dysfunction in Down Syndrome.- Expression of the transcription factor ETS2 in brain of patients with Down Syndrome - evidence against the overexpression-Gene dosage hypothesis.- Neuronal apoptosis inhibitory protein (NAIP)-like immunoreactivity in brains of adult patients with Down Syndrome.- The Gene dosage effect hypothesis versus the amplified developmental instability hypothesis in Down Syndrome.- Downregulation of the transcription factor scleraxis in brain of patients with Down Syndrome.- Heat-shock protein 70 levels in brain of patients with Down Syndrome and Alzheimer's disease.- Increased levels of 14-3-3 Gamma and epsilon proteins in brain of patients with Alzheimer's disease and Down Syndrome.- Application of Alu-splice PCR on chromosome 21: DSCR1 and Intersectin.- Overexpression of DNAse I in brain of patients with Down Syndrome.