The Modeling of Magnetic Detection of Iron Oxide Nanoparticles in the Stream of Patient-Specific Artery With Stenotic Lesion: The Effects of Vessel Geometry and Particle Concentration

Abstract

Magnetic nanoparticles (MNPs) prepared as stable colloidal suspensions dispersed in water have attracted special interest for biological applications. MNPs of iron oxide synthesized by a laser target evaporation (LTE) technique are excellent candidates for biomedical purposes. Magnetic fluid flowing through the blood vessel creates magnetic fields which can be detected by magnetic field sensor. In this work, the finite element method modeling (FEM) was used for calculation of the flow of ferrofluid containing magnetic iron oxide MNPs through a real coronary artery reconstructed from the routine angiography examination of a patient. The main objective of the study is to validate the possibility of the application of magnetic field sensor for the blood vessel geometry evaluation. The contribution of the magnetic susceptibility of MNPs, blood vessel diameter, and particular geometry as well as the orientation of the magnetic field sensor working on the principle of giant magnetoimpedance (GMI) were comparatively analyzed.