The Modeling and Analysis of Mechanisms for lncRNA Regulation

Abstract

Long non-coding RNA- lncRNA is a class of RNA molecule that is found in eukaryotes with a length between 200-100000 nt and no long reading frame, but its structural features are similar to mRNA [1,2]. The achievements in the genomic research project show that in the human genome sequence only 1.5% of nucleic acid sequences are used for protein coding (Data from ENCODE research published in 2012 [3]), 98.5% of DNA sequence in human genome belongs to non-coding sequence, most of the non-coding sequence are transcribed into RNA which length is more than 200 bases so-called “long noncoding RNA”.