Abstract
The aim. The aim of the research was to study the influence of excipients amount on the technological parameters of the compression mixture and tablets based on dry extract of Origanum vulgare L. herb using the method of random balance.
 Materials and methods. Objects of the study – Origanum vulgare L. herb dry extract, 8 excipients that have been studied at two quantitative levels. The tablets were prepared by direct compression method. The formulations were designed according to the method of random balance. The technological parameters of the compression mixture and tablets based on Origanum vulgare L. herb dry extract have been studied as a function of quantitative factors: silicon, magnesium carbonate basic, dioxide magnesium aluminometasilicate (Neusilin S1®), isomalt (GalenIQ™720), F-melt® Type C (co-spray dried excipients), sucralose, berry flavor and citric acid.
 Results and discussion. The increase in the amount of Neusilin S1®, GalenIQ™720 and F-melt®, and the decrease in the amount of magnesium carbonate basic and silicon dioxide improved the flowability expressed by the Hausner ratio. Results of bulk density and tapped density of the compression mixture depended on the quantities of GalenIQ™720 and F-melt®. All formulations of the prepared tablets had the rapid disintegration and ranging from 6 to 15 minutes. Resistance for crushing and friability tablets’ were improved with a decrease in the amount of silicon dioxide and increase in the amount of Neusilin S1®, F-melt® and sucralose. Higher resistance to moisture of tablets based on Origanum vulgare L. dry extract was obtained by using Neusilin S1®, F-melt® and sucralose on the upper levels.
 Conclusions. The tablets based on Origanum vulgare L. herb dry extract were successfully manufactured by direct compression method. The random balance method enabled us to identify the most significant quantitative factors to optimize their composition in the tablets based on the dry extract of Origanum vulgare L. herb.
Highlights
Seasonal influenza which is characterized by a fever, headache, dry cough, muscle and joint pain, feeling unwell, a runny nose and sore throat can cause severe illness or death especially in people at high risk
The aim of our study was to analyze the influence of the amount of excipients on the technological parameters of compression mixture and tablets based on dry extract of Origanum Vulgare L. herb using the method of random balance
The decrease in the amount of silicon dioxide causes the increase in the value of the bulk density and vise versa, the bigger content of GalenIQTM720 is introduced in the compression mixtures, the larger the value of bulk density becomes
Summary
Seasonal influenza which is characterized by a fever, headache, dry cough, muscle and joint pain, feeling unwell, a runny nose and sore throat can cause severe illness or death especially in people at high risk. According to the WHO worldwide statistics, seasonal influenza annual epi demics result in about 3 to 5 million cases of severe illness, and about 290 000 to 650 000 respiratory deaths [1]. We have developed technology of dry extract of this herb and have proved its antimicrobial activity and the anti-inflammatory effect [9]. Thereof tablets based on Origanum vulgare L. herb dry extract are perspective for use in the treatment of the mucous membrane of the upper respiratory tract [11]
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