Abstract
A urinary excretion product following oral administration of tryptophan or indolylacrylic acid to rats, has been identified as indolylacryloylglucosiduronic acid, which accompanies the previously described indolylacryloyl-glycine. Under defined conditions in vitro, rat liver slices or whole homogenates form both these conjugates from the acid. Liver mitochondrial preparations synthesise solely the glycine derivative. Microsomal preparations synthesise solely the acyl-glucuronide, and only when fortified with UDP-glucuronic acid; stimulation of glucuronide formation by saccharolactone, UDP- N-acetyl-glucosamine or various nucleoside- or sugar-phosphates is observed, and is discussed. Glucuronic acid conjugation has not previously been reported with acids of the acrylic or cinnamic type.
Published Version
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