Abstract
Oxidative stress has been suggested to affect age-associated physiological dysfunction. Therefore, it is speculated that antioxidant supplements could have a potential role in preventing age-related diseases and death. Among different dietary habits, the highly antioxidant Mediterranean dietary pattern, which includes high vegetable and fruit intake, consumption of legumes, cereals, and fish, low intake of meat and dairy derivatives, moderate red wine consumption, and use of extra-virgin olive oil, is characterized by other aspects than food, such as conviviality, sensory stimulation, socialization, biodiversity, and seasonality that can reinforce the Mediterranean diet’s (MeD) beneficial effects on wellbeing, quality of life, and healthy aging. The present review aims to discuss available data on the relationship between oxidative stress and aging, biomarkers of oxidative stress status, protective effects of the MeD, and the adoption of the Mediterranean lifestyle as a non-pharmacological and natural tool to cope with oxidative stress damage for a longer life span, and—even more important—healthy aging beyond the biological, psychological, and social challenges that old age entails.
Highlights
Aging is an unavoidable, complex, and multifactorial event leading to progressive loss of function, disability, and death
The biological basis of aging is unknown, oxidative stress is a central determinant in aging theories [1]
The present review aims to discuss available data on the relationship between oxidative stress and aging, biomarkers to assess the oxidative stress status, protective effects of the Mediterranean diet (MeD), and the adoption of the Mediterranean lifestyle as a non-pharmacological and natural tool to cope with oxidative stress damage and prevent aging as well as major degenerative and chronic diseases (cancer, neurodegenerative and cardiovascular (CV) disease)
Summary
Complex, and multifactorial event leading to progressive loss of function, disability, and death. The biological basis of aging is unknown, oxidative stress is a central determinant in aging theories [1]. The possibility to combat oxidative stress with antioxidant strategies—diet, exogenous antioxidant supplementation, or lifestyle changes—appears as an exciting tool to improve wellbeing and health for healthy aging. The present review aims to discuss available data on the relationship between oxidative stress and aging, biomarkers to assess the oxidative stress status, protective effects of the MeD, and the adoption of the Mediterranean lifestyle as a non-pharmacological and natural tool to cope with oxidative stress damage and prevent aging as well as major degenerative and chronic diseases (cancer, neurodegenerative and cardiovascular (CV) disease)
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