Abstract
Background: Chronic kidney disease entails a high disease burden that is progressively increasing due to population aging. However, evidence on the effect of the Mediterranean diet on renal function is limited, in particular among older adults in Mediterranean countries. Methods: Prospective cohort study with 975 community-dwelling adults aged ≥ 60 recruited during 2008–2010 in Spain and followed up to 2015. At baseline, food consumption was obtained using a validated dietary history. Two Mediterranean dietary patterns were used: (i) An a priori-defined pattern, the Mediterranean Diet Adherence Screener (MEDAS score: low adherence: 0–5 points; moderate: 6–8 points; high: 9–14 points); (ii) An a posteriori Mediterranean-like dietary pattern, based on 36 food groups, which was generated using factor analysis. Renal function decline was calculated as an estimated glomerular filtration rate (eGFR) decrease ≥1 mL/min/1.73 m2 per year of follow-up. Results: A total of 104 cases of renal function decline occurred. Compared with participants with a low MEDAS adherence, the multivariable-adjusted odds ratios (95% confident interval) for renal function decline risk were 0.63 (0.38–1.03) for moderate adherence, and 0.52 (0.29–0.95) for high adherence (p-trend: 0.015). Multivariable-adjusted odds ratios (95% confidence interval) for renal function decline risk according to increasing quartiles of the adherence to the a posteriori Mediterranean-like dietary pattern were 1.00, 0.67 (0.38–1.20), 0.65 (0.35–1.19), and 0.47 (0.23–0.96) (p-trend: 0.042). Conclusion: A higher adherence to a Mediterranean diet was associated with a lower risk of renal function decline in older adults, suggesting benefits to health of this dietary pattern in Mediterranean countries.
Highlights
Compared to individuals with a low adherence to the MEDAS index, those with a moderate adherence had a risk of renal function decline of odds ratios (OR): 0.63, and those with a high adherence had a significantly lower risk OR: 0.52; p-trend 0.015 (Table 2, model 3)
A recent meta-analysis conducted with eight observational studies confirmed that healthy dietary patterns are linked to a reduced incidence of Chronic kidney disease (CKD) and incidence of albuminuria, but the association did not reach significance for estimated glomerular filtration rate (eGFR) decline [3]
One of the meta-analyzed studies showed that the adherence to the Mediterranean diet was linked to a lower incidence of CKD in a population-based cohort of older men, as well as to a reduced mortality risk in patients with manifest CKD [6]
Summary
CKD is related to an increase in all-cause and cardiovascular mortality, and renal function impairment involves a substantial economic and social burden on the general population. Chronic kidney disease entails a high disease burden that is progressively increasing due to population aging. Two Mediterranean dietary patterns were used: (i) An a priori-defined pattern, the Mediterranean Diet Adherence Screener (MEDAS score: low adherence: 0–5 points; moderate: 6–8 points; high: 9–14 points); (ii) An a posteriori Mediterranean-like dietary pattern, based on 36 food groups, which was generated using factor analysis. Compared with participants with a low MEDAS adherence, the multivariable-adjusted odds ratios (95% confident interval) for renal function decline risk were 0.63 (0.38–1.03) for moderate adherence, and 0.52 (0.29–0.95) for high adherence (p-trend: 0.015). Multivariable-adjusted odds ratios (95% confidence interval) for renal function decline risk according to increasing quartiles of the adherence to the a posteriori
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
